פרופ' מיכאל פרידמן

Research Keywords:

• Controlled-release for pharmaceuticals
• CR in oral cavity
• Injectable CR
• Gastroretentive dosage forms
• Orthopedic membranes for guided bone regeneration
• Thermosensitive depot systems
• Cannabinoids

Research Highlights:

Oral delivery

• Gastroretentive dosage forms: floating, unfolding, synergy-assisted mechanisms. Unfolding dosage forms include several POC studies with levodopa, furosemide, and riboflavin. Floating and synergy systems developed with gabapentin, polyphenols and cannabinoids models.
• Novel excipients for modified-release tablets: proved with carbamazepine, valporoic acid, theophilline, and other model drugs.

Local delivery

• Controlled-release for oral cavity – antiseptics, antifungals; liquid (varnish etc) and solid (Periochip) dosage forms.
• Orthopedic membranes for guided bone regeneration, including drug-eluting membranes that support mesenchymal stem cells.

Injectables

• Thermosensitive depot systems for veterinary medicine
• Rapidly solidifying implants for dental and systemic applications, including orthopedics