פרופ' דמיטרי צבליחובסקי

Research Keywords:

• Synthetic Medicinal Chemistry
• Molecular Cages Design and Applications
• Psychedelic Drugs Development
• Data-Driven Drug Discovery and Screening
• Antibiotics Development
• Synthetic Methodology Innovation

Research Highlights:

The Tsvelikhovsky Research Group focuses on innovative approaches in synthetic organic chemistry to address major challenges in medicine. Their work pioneers the design of molecular cages for drug development, enabling precise targeting of receptor sites to enhance therapeutic efficacy while minimizing side effects. They also advance neuropharmacology by synthesizing hybrid compounds, such as Confludelycs, which integrate multiple pharmacophores to modulate complex receptor systems like Sigma-1, 5-HT7, and 5-HT2A. In antibiotic development, the group employs a novel matrix synthesis approach to generate structurally unique compounds capable of combating multidrug-resistant pathogens. Their research leverages computational tools, including Schrödinger’s Maestro, to model drug-receptor interactions and optimize structural frameworks. By integrating synthetic innovation with neuropharmacological insights, the group aims to redefine the boundaries of modern drug discovery and design.