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Our lab focuses on pharmacoepidemiology and drug safety, with an emphasis on vulnerable populations such as the elderly, children, and patients with end-stage renal disease (ESRD). We investigate how medications affect these groups by conducting big-data observational studies, including cohort and case-control designs or network meta-analyses. Our research utilizes large healthcare databases to assess real-world medication use and outcomes. By applying advanced epidemiological methods, we aim to identify potential drug-related risks and improve therapeutic safety. A key aspect of our work is understanding how comorbidities and physiological differences influence drug response. We strive to generate evidence that informs clinical guidelines and regulatory decisions for safer, more effective medication use in special populations.